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- W2390949628 abstract "Objective To investigate the possibility of protection of intestinal epithelial cells against hypoxia-reoxygenation through recombinant adenovirus-mediated Bcl-2 gene transfection.Methods Replication defective recombinant adenoviral vector Ad/CMV-Bcl-2 had been constructed with full length human Bcl-2 gene.The overexpression of Bcl-2 gene was detected by RT-PCR in transfected groups.After the cells suffered 1hour of hypoxia followed by 1 hour of reoxygenation,the effects of transfected Bcl-2 gene overexpression were studied.The cell viability was analyzed by MTT method,and the apoptosis and dead cell ratio were evaluated with Annexin-V-Flous stained kit in vitro.Results The expression of Bcl-2 was positive in the Ad/CMV-Bcl-2 transfected intestinal epithelial cells and negative in the control group.After hypoxia-reoxygenation,the cell viability rates of Bcl-2 gene transfected groups were all significantly higher than that of control group(P0.01).while the apoptosis rates of Bcl-2 gene transfected groups were significantly lower than that of control group (P0.01).Conclusion The experimental results of transfection in vitro showed the indeed protection of the injury intestinal epithelial cells caused by the hypoxia/reoxygenation." @default.
- W2390949628 created "2016-06-24" @default.
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- W2390949628 date "2010-01-01" @default.
- W2390949628 modified "2023-09-23" @default.
- W2390949628 title "Protective effects of adenovirus-mediated Bcl-2 gene transfection for the intestinal epithelial cells against hypoxia-reoxygenation in vitro" @default.
- W2390949628 hasPublicationYear "2010" @default.
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