Matches in SemOpenAlex for { <https://semopenalex.org/work/W2390951072> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2390951072 endingPage "491" @default.
- W2390951072 startingPage "489" @default.
- W2390951072 abstract "OBJECTIVE The beta-D-endoglycosidase heparanase (Hpa) is HS-specific which leads to heparan sulfate (HS) degradation. An increased permeability of the glomerular basement membrane (GBM) for proteinuria is related with a decreased HS side chains of the GBM. However, whether an up-regulated expression of Hpa exists in nephrotic syndrome (NS) remains unknown. The purpose of this study was to evaluate the role of Hpa in the development of NS and the relevance to proteinuria. METHODS NS was induced in SD rats by tail intravenous injection of 5 mg/kg Adriamycin. Rats were housed in the metabolic cages for 24 hours to collect urine prior to induction of disease and at day 7 and 14 following disease induction. By using the method of reverse transcriptase-PCR (RT-PCR), Hpa gene from the peripheral blood leukocytes of these rats was assayed. RESULTS The resulting cDNA fragment was consistent with rat heparanase mRNA sequence in GenBank (accession number AF184963). The rats at day 7 and 14 showed significantly up-regulated Hpa mRNA expression in contrast to the normal rats. There was a significant correlation between the level of Hpa mRNA and the quantification of urinary protein (r=0.925, P<0.001). CONCLUSION Up-regulated expression of Hpa mRNA may be an important contributor to loss of glomerular negative charge in GBM and hence may lead to proteinuria in nephrotic syndrome." @default.
- W2390951072 created "2016-06-24" @default.
- W2390951072 creator A5029554405 @default.
- W2390951072 creator A5048411184 @default.
- W2390951072 creator A5072199362 @default.
- W2390951072 date "2004-07-01" @default.
- W2390951072 modified "2023-09-23" @default.
- W2390951072 title "Gene expression of heparanase in peripheral blood leukocytes from rats with nephrotic syndrome and its relationship to proteinuria" @default.
- W2390951072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15291107" @default.
- W2390951072 hasPublicationYear "2004" @default.
- W2390951072 type Work @default.
- W2390951072 sameAs 2390951072 @default.
- W2390951072 citedByCount "0" @default.
- W2390951072 crossrefType "journal-article" @default.
- W2390951072 hasAuthorship W2390951072A5029554405 @default.
- W2390951072 hasAuthorship W2390951072A5048411184 @default.
- W2390951072 hasAuthorship W2390951072A5072199362 @default.
- W2390951072 hasConcept C104317684 @default.
- W2390951072 hasConcept C105580179 @default.
- W2390951072 hasConcept C126322002 @default.
- W2390951072 hasConcept C134018914 @default.
- W2390951072 hasConcept C150194340 @default.
- W2390951072 hasConcept C185592680 @default.
- W2390951072 hasConcept C2777478136 @default.
- W2390951072 hasConcept C2777557582 @default.
- W2390951072 hasConcept C2778041096 @default.
- W2390951072 hasConcept C2778930706 @default.
- W2390951072 hasConcept C2779561371 @default.
- W2390951072 hasConcept C2780091579 @default.
- W2390951072 hasConcept C2781175652 @default.
- W2390951072 hasConcept C55493867 @default.
- W2390951072 hasConcept C71924100 @default.
- W2390951072 hasConcept C86803240 @default.
- W2390951072 hasConceptScore W2390951072C104317684 @default.
- W2390951072 hasConceptScore W2390951072C105580179 @default.
- W2390951072 hasConceptScore W2390951072C126322002 @default.
- W2390951072 hasConceptScore W2390951072C134018914 @default.
- W2390951072 hasConceptScore W2390951072C150194340 @default.
- W2390951072 hasConceptScore W2390951072C185592680 @default.
- W2390951072 hasConceptScore W2390951072C2777478136 @default.
- W2390951072 hasConceptScore W2390951072C2777557582 @default.
- W2390951072 hasConceptScore W2390951072C2778041096 @default.
- W2390951072 hasConceptScore W2390951072C2778930706 @default.
- W2390951072 hasConceptScore W2390951072C2779561371 @default.
- W2390951072 hasConceptScore W2390951072C2780091579 @default.
- W2390951072 hasConceptScore W2390951072C2781175652 @default.
- W2390951072 hasConceptScore W2390951072C55493867 @default.
- W2390951072 hasConceptScore W2390951072C71924100 @default.
- W2390951072 hasConceptScore W2390951072C86803240 @default.
- W2390951072 hasIssue "4" @default.
- W2390951072 hasLocation W23909510721 @default.
- W2390951072 hasLocation W23909510722 @default.
- W2390951072 hasOpenAccess W2390951072 @default.
- W2390951072 hasPrimaryLocation W23909510721 @default.
- W2390951072 hasRelatedWork W2013203608 @default.
- W2390951072 hasRelatedWork W2081975404 @default.
- W2390951072 hasRelatedWork W2085247945 @default.
- W2390951072 hasRelatedWork W2107668112 @default.
- W2390951072 hasRelatedWork W2108358727 @default.
- W2390951072 hasRelatedWork W2183511502 @default.
- W2390951072 hasRelatedWork W2277251350 @default.
- W2390951072 hasRelatedWork W2352069375 @default.
- W2390951072 hasRelatedWork W2355562419 @default.
- W2390951072 hasRelatedWork W2357916902 @default.
- W2390951072 hasRelatedWork W2369138398 @default.
- W2390951072 hasRelatedWork W2372320074 @default.
- W2390951072 hasRelatedWork W2377328533 @default.
- W2390951072 hasRelatedWork W2381612189 @default.
- W2390951072 hasRelatedWork W2391698882 @default.
- W2390951072 hasRelatedWork W2421664766 @default.
- W2390951072 hasRelatedWork W2472766566 @default.
- W2390951072 hasRelatedWork W2893771854 @default.
- W2390951072 hasRelatedWork W3143074062 @default.
- W2390951072 hasRelatedWork W3144788734 @default.
- W2390951072 hasVolume "35" @default.
- W2390951072 isParatext "false" @default.
- W2390951072 isRetracted "false" @default.
- W2390951072 magId "2390951072" @default.
- W2390951072 workType "article" @default.