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- W2390955247 abstract "Objective To investigate the changes of plasma levels of endothelin(ET-1)and glucagon(GLU)in cirrhotic patients and its effect in the pathogenesis of portal hypertension.Methods Plasma levels of ET-1 and GLU were measured by radioimmunoassay(RIA)in 40 patients with liver cirrhosis and 18 healthy controls.The max diameters,mean flow velocity,flow rate of the portal vein trunks(PV)and splenic veins(SV)were detected by Color Doppler Ultrasound.Results Plasma levels of ET-1 and GLU in cirrhotic patients were significantly higher than those in controls and were increased with the severity of hepatic function impairment as assessed by Child-Pugh grade.Patients with ascites showed significant higher plasma ET-1 and GLU levels than those without ascites.Plasma levels of ET-1 and GLU were positively correlated with portal vein diameters,splenic vein diameters and splenic vein flows.Conclusion The increase of plasma ET-1 and GLU levels reflects,in part,the severity of impairment of hepatic function.In addition,it may contribute to the pathogenesis of portal hypertension." @default.
- W2390955247 created "2016-06-24" @default.
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- W2390955247 date "2003-01-01" @default.
- W2390955247 modified "2023-09-24" @default.
- W2390955247 title "Changes of plasma levels of ET-1 and glucagon in cirrhotic patients and its clinical value" @default.
- W2390955247 hasPublicationYear "2003" @default.
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