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- W2390962021 abstract "Objective To establish human induced pluripotency stem cell (iPSC) lines by lenti-viral transfection and induce iPSC differentiated to neuroepithelial cells(NECs), then to create a new model for the study of early neural development of human embryos and provide a new option of treatment to transplant for nerve system disease. Methods Lenti-viral system was used to transfect human lung fibroblast cells with combination of 6 transcription factors:octamer-binding transcription factor-4 (OCT4), sex determining region Y (SRY)-box 2 (SOX2), Kruppel-like factor 4 (KLF4), Nanog homebox(NANOG), Lin-28 homolog(LIN28) and c-Myc to induce iPSC after screening, then NECs were induced in vitro by adding several growth factors.Results Human iPSC lines were successfully derived from human fibroblast cells which shared the same background and owe similar morphology and pluripotency as human embryonic stem cell (hESC). iPSC could be induced in vitro to differentiate into neural cells with similar efficiency of differentiation as hESC. Conclusion Human iPSC lines can be derived by lenti-viral system and induced into neural cells, which may be very useful for construction of disease model and understanding the mechanisms for neurological degenerative and neurogenetic diseases." @default.
- W2390962021 created "2016-06-24" @default.
- W2390962021 creator A5020688307 @default.
- W2390962021 date "2010-01-01" @default.
- W2390962021 modified "2023-09-23" @default.
- W2390962021 title "Specific inducement of human induced pluripotency cells to trophoblast cells" @default.
- W2390962021 hasPublicationYear "2010" @default.
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