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- W2390973553 abstract "Objective:To investigate the immunological reaction state of Th1/Th2 cytokines expression in human lung cancer cell lines and the peripheral blood mononuclear cells(PBMCs) from patients with lung cancer,and evaluate the effect of astragalus(AG) on them.Methods:The cells from three kinds of human lung cancer cell lines were divided into 5 groups:one group as pre cultured group,and the other cells were cultured with 5% AG,10% AG,20% AG and without AG(control group),respectively.The PBMCs from patients were divided into 4 groups:one group as pre cultured group,and the other cells were cultured with 10% AG,20% AG and without AG (control group),respectively.Three kinds of human lung cancer cell lines and PBMC from 23 lung cancer patients as well as 19 healthy controls before and after the culture with AG were collected respectively.The Th1/Th2 cytokines expression were detected by RT PCR considering IFN γ and IL 2 as Th1 cytokines and IL 4,IL 6,IL 10 as Th2 ones.Results:None of the human lung cancer cell lines expressed IL 2 and IFN γ,whereas IL 4,IL 6,IL 10 were expressed in pre cultured and control groups.After the culture with AG,the expression of IFN γ was induced,while that of IL 4,IL 6 was inhibited,especially in SCL.The m RNA expression rates of IL 4,IL 6,IL 10 in PBMCs from lung cancer patients were obviously higher than those from the healthy controls ( P0.05) ?IL 2 expression was not detected in all patients(0/23),and the positive rate of IFN γ expression was 1/23;After being cultured with AG,the expressions of Th1/Th2 cytokines were changed obviously ,which was refleted by a significant enhancement in IL 2 expression paralleled by a substantial decrease in IL 4,IL 6 and IL 10.Conclusion:The expression of Th1 cytokines was inhibited with a concomitant predominant state of Th2 cytokines in both human lung cancer cell lines and PBMCs from lung cancer patients.AG can convert the imbalant state of Th1/Th2 cytokines and make it incline to the normal state." @default.
- W2390973553 created "2016-06-24" @default.
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- W2390973553 date "2001-01-01" @default.
- W2390973553 modified "2023-09-25" @default.
- W2390973553 title "PATTERN OF TH1/TH2 AND REGULATION OF ASTRAGALUS IN LUNG CANCER" @default.
- W2390973553 hasPublicationYear "2001" @default.
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