Matches in SemOpenAlex for { <https://semopenalex.org/work/W2390973851> ?p ?o ?g. }
- W2390973851 endingPage "1109" @default.
- W2390973851 startingPage "1100" @default.
- W2390973851 abstract "<h3>BACKGROUND:</h3> Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and fatal interstitial lung disease associated with poor prognosis and limited effective treatment options. Reliable predictors of outcome in daily clinical practice are needed to determine high-risk patients for urgent lung transplantation referral. This study aimed to identify practical prognostic predictors of mortality using cardiopulmonary exercise testing (CPET) in IPF subjects. <h3>METHODS:</h3> Thirty-four subjects with IPF (22 men and 12 women), median age 68 (range 50–81) y were prospectively studied. At baseline, all subjects were assessed with CPET and were followed up for 40 months from baseline. Receiver operating characteristic curve analysis was conducted to determine cut-off points of CPET variables for mortality, Cox regression analysis for survival using a log-rank test, and hazard ratio for death using a Wald test. <h3>RESULTS:</h3> Peak work rate <62 watts (<i>P</i> = .005), peak V̇<sub>O<sub>2</sub></sub> ≤13.8 mL/kg/min (<i>P</i> = .031), tidal volume reserve ≤0.48 L/breath (<i>P</i> = .010), minute ventilation to carbon dioxide (V̇<sub>E</sub>)/V̇<sub>CO<sub>2</sub></sub>) ratio at the anaerobic threshold >34 (<i>P</i> = .02), and V̇<sub>E</sub>)/V̇<sub>O<sub>2</sub></sub> nadir >34 (<i>P</i> = .002) were detected as cut-off points associated with mortality. Non-survivor subjects were characterized by higher dyspnea levels, the presence of pulmonary hypertension assessed by echocardiography, pronounced inefficient ventilatory pattern, lower exercise capacity, and more severe desaturation during physical exertion. By the end of the study, 11 subjects (7 women and 4 men) died. Overall mean survival was 60%, 33.7 months (95% CI 30.2–37.2). <h3>CONCLUSIONS:</h3> This study provides simple, practical, and novel cut-off points for CPET as predictors of prognosis to identify high-risk IPF subjects. Impairment in exercise capacity and abnormal ventilatory responses during CPET were associated with poorer survival in IPF subjects. The findings suggest considering the use of CPET for IPF risk stratification and prediction of prognosis. (ClinicalTrials.gov registration NCT01499745.)" @default.
- W2390973851 created "2016-06-24" @default.
- W2390973851 creator A5011129057 @default.
- W2390973851 creator A5020974544 @default.
- W2390973851 creator A5031125410 @default.
- W2390973851 creator A5039316416 @default.
- W2390973851 date "2016-05-10" @default.
- W2390973851 modified "2023-09-26" @default.
- W2390973851 title "The Prognostic Role of Ventilatory Inefficiency and Exercise Capacity in Idiopathic Pulmonary Fibrosis" @default.
- W2390973851 cites W1513562286 @default.
- W2390973851 cites W1524830325 @default.
- W2390973851 cites W1531237901 @default.
- W2390973851 cites W1548223836 @default.
- W2390973851 cites W1860863518 @default.
- W2390973851 cites W1964749849 @default.
- W2390973851 cites W1987197759 @default.
- W2390973851 cites W1988226846 @default.
- W2390973851 cites W1991660435 @default.
- W2390973851 cites W1994836525 @default.
- W2390973851 cites W2016763119 @default.
- W2390973851 cites W2033661946 @default.
- W2390973851 cites W2033690859 @default.
- W2390973851 cites W2039943389 @default.
- W2390973851 cites W2044353077 @default.
- W2390973851 cites W2064164967 @default.
- W2390973851 cites W2064594004 @default.
- W2390973851 cites W2065106161 @default.
- W2390973851 cites W2067464606 @default.
- W2390973851 cites W2070827998 @default.
- W2390973851 cites W2074602210 @default.
- W2390973851 cites W2076579116 @default.
- W2390973851 cites W2084029271 @default.
- W2390973851 cites W2096751910 @default.
- W2390973851 cites W2100710359 @default.
- W2390973851 cites W2117488044 @default.
- W2390973851 cites W2129887930 @default.
- W2390973851 cites W2134867579 @default.
- W2390973851 cites W2135577046 @default.
- W2390973851 cites W2137502151 @default.
- W2390973851 cites W2137731450 @default.
- W2390973851 cites W2138165175 @default.
- W2390973851 cites W2141922649 @default.
- W2390973851 cites W2146965595 @default.
- W2390973851 cites W2149533973 @default.
- W2390973851 cites W2156880877 @default.
- W2390973851 cites W2167383172 @default.
- W2390973851 cites W2197553214 @default.
- W2390973851 cites W2442868874 @default.
- W2390973851 cites W2626588662 @default.
- W2390973851 cites W3095078287 @default.
- W2390973851 cites W67511064 @default.
- W2390973851 doi "https://doi.org/10.4187/respcare.04471" @default.
- W2390973851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27165419" @default.
- W2390973851 hasPublicationYear "2016" @default.
- W2390973851 type Work @default.
- W2390973851 sameAs 2390973851 @default.
- W2390973851 citedByCount "36" @default.
- W2390973851 countsByYear W23909738512016 @default.
- W2390973851 countsByYear W23909738512017 @default.
- W2390973851 countsByYear W23909738512018 @default.
- W2390973851 countsByYear W23909738512019 @default.
- W2390973851 countsByYear W23909738512020 @default.
- W2390973851 countsByYear W23909738512021 @default.
- W2390973851 countsByYear W23909738512022 @default.
- W2390973851 countsByYear W23909738512023 @default.
- W2390973851 crossrefType "journal-article" @default.
- W2390973851 hasAuthorship W2390973851A5011129057 @default.
- W2390973851 hasAuthorship W2390973851A5020974544 @default.
- W2390973851 hasAuthorship W2390973851A5031125410 @default.
- W2390973851 hasAuthorship W2390973851A5039316416 @default.
- W2390973851 hasBestOaLocation W23909738511 @default.
- W2390973851 hasConcept C126322002 @default.
- W2390973851 hasConcept C164705383 @default.
- W2390973851 hasConcept C1862650 @default.
- W2390973851 hasConcept C207103383 @default.
- W2390973851 hasConcept C2777714996 @default.
- W2390973851 hasConcept C2778341716 @default.
- W2390973851 hasConcept C2780930700 @default.
- W2390973851 hasConcept C2781448352 @default.
- W2390973851 hasConcept C2911091166 @default.
- W2390973851 hasConcept C44249647 @default.
- W2390973851 hasConcept C50382708 @default.
- W2390973851 hasConcept C5140985 @default.
- W2390973851 hasConcept C71924100 @default.
- W2390973851 hasConceptScore W2390973851C126322002 @default.
- W2390973851 hasConceptScore W2390973851C164705383 @default.
- W2390973851 hasConceptScore W2390973851C1862650 @default.
- W2390973851 hasConceptScore W2390973851C207103383 @default.
- W2390973851 hasConceptScore W2390973851C2777714996 @default.
- W2390973851 hasConceptScore W2390973851C2778341716 @default.
- W2390973851 hasConceptScore W2390973851C2780930700 @default.
- W2390973851 hasConceptScore W2390973851C2781448352 @default.
- W2390973851 hasConceptScore W2390973851C2911091166 @default.
- W2390973851 hasConceptScore W2390973851C44249647 @default.
- W2390973851 hasConceptScore W2390973851C50382708 @default.
- W2390973851 hasConceptScore W2390973851C5140985 @default.
- W2390973851 hasConceptScore W2390973851C71924100 @default.
- W2390973851 hasIssue "8" @default.