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- W2390975898 abstract "AIM:To examine the pathological changes of ovaries and the effects of the expression of mRNA transcripts of FSH receptor in ovaries of the rats exposed to chemotherapeutic drugs.METHODS:Twenty rats were randomly assigned into two groups:cyclophosphamide group and normal saline group,who received a single injection of the saline or chemotherapeutic agent cyclophosphamide.Animals were sacrificed after 8 weeks of treatment.Ovarian pathological changes were observed and follicle number was counted.FSH mRNA was quantified using real-time PCR.RESULTS:Cyclophosphamide had a detrimental effect on ovarian stromal function.The rats in cyclophosphamide group developed a lower proportion of antral follicles compared with control group(P0.05).FSHR mRNA content was significantly lower in the cyclophosphamide treatment group than in the control group(P0.05).There was a significant positive correlation between FSHR and antral proportion and a significant negative correlation between FSHR and duration for estrous cycle(P0.05).CONCLUSION:In ovaries exposed to cyclophosphamide lower,there is lower level of FSHR,which may be involved in antral follicle development blockade and may be associated with prolonged estrous cycle." @default.
- W2390975898 created "2016-06-24" @default.
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- W2390975898 date "2008-01-01" @default.
- W2390975898 modified "2023-09-24" @default.
- W2390975898 title "In vivo expression of FSHR in rats ovaries after exposure to cyclophosphamide" @default.
- W2390975898 hasPublicationYear "2008" @default.
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