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• W2390979291 abstract "Platelets contain not only proteins needed for hemostasis but also many growth factors that are required for organ development, tissue regeneration, and repair. Thrombocytopenia, which is frequently observed in patients with chronic liver disease (CLD) and cirrhosis, is due to various causes, such as decreased thrombopoietin production and accelerated platelet destruction caused by hypersplenism; however, the relationship between thrombocytopenia and hepatic pathogenesis and the role of platelets in CLD are poorly understood. Thus, in this paper, the experimental evidence for platelets improving liver fibrosis and accelerating liver regeneration is summarized and addressed based on studies conducted in our laboratory and current progress reports from other investigators. Platelets improve liver fibrosis by inactivating hepatic stellate cells to decrease collagen production. The level of intracellular cAMP is increased by adenosine through its receptors on hepatic stellate cells, thereby resulting in inactivation of these cells. Adenosine is produced by degradation of adenine nucleotides, which are stored in abundance within the dense granules of platelets. The regenerative effect of platelets in the liver consists of three mechanisms: a direct effect on hepatocytes, a cooperative effect with liver sinusoidal endothelial cells, and a collaborative effect with Kupffer cells. Based on these experiments, a clinical trial suggested that the increase in platelets induced by platelet transfusion improved liver function in patients with CLD in a clinical setting.We highlight the current knowledge concerning the role of platelets in CLD and expect to open a novel avenue for application of these clinical therapies to treat liver disease." @default.
• W2390979291 created "2016-06-24" @default.
• W2390979291 creator A5035600709 @default.
• W2390979291 creator A5036178163 @default.
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• W2390979291 date "2016-04-01" @default.
• W2390979291 modified "2023-09-24" @default.
• W2390979291 title "Novel functions of platelets in the liver" @default.
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• W2390979291 doi "https://doi.org/10.1111/jgh.13244" @default.
• W2390979291 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26632220" @default.
• W2390979291 hasPublicationYear "2016" @default.
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