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- W2390985601 abstract "Objective:To observe the effects of Zuogui Wan and Yougui Wan on the expression of learning and memory related signal transduction proteins.Methods:The nature old SD rats were used as senile animal model.The rats were randomly divided into five groups:young group(aged 5 month),senile group(aged 24 month),senile+antagonist RU38486(aged 24 month),senile+Zuogui Wan group(aged 24 month),senile+Yuogui Wan group(aged 24 month).The expression of learning and memory related signal transduction proteins were tested by Western blot method.The regulating effects of kidney-tonifying recipe on above indices were also studied.Results:Compared with young group,the expression of the proteins-CaM,pCaMKⅡ,pERK1/2,pCREB,pSynapsin-1 and Arc were obviously decreased(P0.05).Zuogui Wan and Yougui Wan,however,could improve the abnormal changes of these indices in senile rats to varying degrees.Conclusion:Zuogui Wan and Yougui Wan could improve spatial learning momory abilities of senile rats through retarding aging changes of the expression of related signal transduction proteins." @default.
- W2390985601 created "2016-06-24" @default.
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- W2390985601 date "2012-01-01" @default.
- W2390985601 modified "2023-09-28" @default.
- W2390985601 title "Effects of Zuogui Wan and Yougui Wan on the expression of learning and memory related signal transduction proteins" @default.
- W2390985601 hasPublicationYear "2012" @default.
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