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- W2390990136 abstract "OBJECTIVE To prepare bovine serum albumin magnetic deuto-microspheres of fluorouracil(FU-AMDM) and study their properties.METHODS The magnetic deuto-microspheres were prepared by emulsion-ultrasound-heat stabilization techniques.The shape and size distribution were observed. High-performance liquid chromatography was used to determine the content of fluorouracil. The release test of FU from AMDM in vitro was carried out by using constant temperature vibration dialysis assay.The targeting property was studied in tumor-bearing mice. RESULTS The mean diameter of FU-AMDM was (321±50)nm,with the range from 100 nm to 600 nm. The drug loading and drug trapping efficiency of FU-AMDM were (9.69±0.19)% and (70.36±0.53)%,respectively. The drug release profile was described by Higuchi equation. The drug concentration in tumor tissues was higher than other sites. CONCLUSION FU-AMDM has potential prospects in sustained release and targeted localization,and will be used in targeting drug delivery system." @default.
- W2390990136 created "2016-06-24" @default.
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- W2390990136 date "2007-01-01" @default.
- W2390990136 modified "2023-09-23" @default.
- W2390990136 title "Study on Properties in vitro of Fluorouracil Albumin Magnetic Deuto-Microspheres" @default.
- W2390990136 hasPublicationYear "2007" @default.
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