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- W2391005320 abstract "Objective To observe the specific cellular immunologic repsonses and the protection against P815 mastocytoma cells stably expressing HBV surface antigen (P815 HBV S) in BALB/c(H 2 d) mice after immunization of HBV DNA vaccine (pCR3.1 S).Methods The immunization was performed by intramuscular injection in this experiment. Three weeks later, P815 HBV S was directly inoculated into mice by subcutaneous route. The size of the grow of the tumor growth was measured every five days and HBsAg specific cytotoxic T lymphocytes (CTLs) activity was measured by 51 Chromium release assay.Results HBV S DNA vaccine can evidently inhibit the tumor growth, prolong the survival period and improve the survival rate in these mice. The HBsAg specific CTLs activity increased obviously after HBV DNA vaccination.Conclusion The results show that the DNA vaccine of pCR3.1 S has strong antigenecity in cellular immunity and has marked killing effect on HBV infected cell in vivo. DNA vaccine against HBV may be useful for both prophylactic and therapeutic purposes." @default.
- W2391005320 created "2016-06-24" @default.
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- W2391005320 date "2000-01-01" @default.
- W2391005320 modified "2023-09-26" @default.
- W2391005320 title "Specific cellular immunity and antitumor responses in H 2~d mice induced by DNA vaccine" @default.
- W2391005320 hasPublicationYear "2000" @default.
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