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- W2391007930 abstract "We hypothesized that diet-metformin (MET) promote successful live births in women with polycystic ovary syndrome (PCOS) by lowering hypofibrinolytic plasminogen activator inhibitor (PAI-Fx) during the 1st two trimesters of pregnancy. We studied 43 women with PCOS, 21 with live births, 22 with 1st trimester miscarriages. Women with BMI 0.1) at pre-treatment (pre-Rx) study entry by median age (28 vs 30 years), BMI (33.6 vs 34.9), serum insulin (24 vs 20 μU/mL), HOMA insulin resistance (IR) (5.07 vs 4.42), HOMA insulin secretion (342 vs 240), PAI-Fx (18.8 vs 11.7 u/mL), or race (95% vs 100% white). At pre-Rx baseline, in the 21 live birth pregnancies, median PAI-Fx was 18.8 u/mL, fell on MET-diet to 11.4 at the last pre-conception visit, fell to 8.6 at the end of the 1st trimester, and was 11.7 at the end of the 2nd trimester (p .05). In the live birth group, on diet-MET for 12 months pre-conception, PAI-Fx fell 54% (p =.051) from pre-Rx baseline to the last pre-conception visit. In the miscarriage group, on diet-MET for 9 months pre-conception, PAI-Fx rose 19% from pre-Rx baseline to the last pre-conception visit, differing from the live birth group (p = .01). From pre-Rx baseline to the 1st trimester, live birth and miscarriage groups both lost weight (9.7% [p" @default.
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- W2391007930 date "2005-03-01" @default.
- W2391007930 modified "2023-09-27" @default.
- W2391007930 title "56 PLASMINOGEN ACTIVATOR INHIBITOR ACTIVITY DURING PREGNANCY IN 43 WOMEN WITH POLYCYSTIC OVARY SYNDROME, 21 WITH LIVE BIRTHS, 22 WITH MISCARRIAGES" @default.
- W2391007930 doi "https://doi.org/10.2310/6650.2005.00205.55" @default.
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