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- W2391012992 abstract "AIM: To investigate the effects of advanced glycation end products(AGEs) on proliferation of human periodontal ligament stem cells(HPDLSCs) and expressions of DKK-1 and β-catenin,genes of Wnt signaling pathway.METHODS: PDLSCs were isolated and cultured by limited dilution method to single clones.Flow cytometry was employed to study the surface markers of the cloned cells.Single clones of PDLSCs were stimulated with 100 g/mL of AGEs.Proliferation of PDLSCs was measured by MTT assay.After 7 days stimulation,mRNA and nuclear proteins were extracted to determined the gene and protein expression of beta catenin and DKK-1 by real-time quantitative polymerase chain reaction(real time PCR) and Westen blot.RESULTS:Clone formation rates of unstimulated and stimulated PDLSCs were 1.6% and 17.2%,respectively(P0.05).The proliferation rate of stimulated PDLSCs was significantly lower than that of the mstimulatad group by MTT assay.The mRNA and protein expression of beta catenin was significantly higher in unstimulated PDLSCs,whereas DKK-1 expression was significantly lower in unstimulated PDLSCs as compared with AGEs stimulated cells(P﹤0.05).CONCLUSION: AGEs may inhibit the proliferation of human periodontal ligament stem cells by suppressing the gene expression of Wnt signaling pathways." @default.
- W2391012992 created "2016-06-24" @default.
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- W2391012992 date "2012-01-01" @default.
- W2391012992 modified "2023-09-23" @default.
- W2391012992 title "Effects of advanced glycation end products on proliferation of human periodontal ligament stem cells and Wnt signaling" @default.
- W2391012992 hasPublicationYear "2012" @default.
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