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- W2391024104 abstract "Sodium 4-methoxypyridinethione(SMPT),in vitro,possesses a significant inhibitory effect on human tumor cell strains,such as Hela,CNE-2 and Raji cell strain.In vivo,it has not inhibitory effect on the transplanted tumors,such as S180,LLC and EC,but significantly enhance the inhibitory effects of 5-Fu on S180.SMPT markedly decreases the weight of spleen and thymus,suppresses the serum hemolysins reaction induced by SRBC in mice and skin delayed type hypersensitivity reaction induced by DNCB in guineapigs.It also inhibits lyphocyte transformation induced by PHA.All these effects are shown the more the dose,the better the effect.Experiments show that SMPT is a antitumor and immuno-inhibitory compound.Compared with sodium pyridinethion(SPT),SMPT has higher LD50 in mice,However,IC50 of both SPT and SMPT has no Significant difference,in vitro." @default.
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- W2391024104 date "1996-01-01" @default.
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- W2391024104 title "Studies on antitumor and immunosuppression effects of sodium 4-methoxypyridinethione" @default.
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