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- W2391039863 abstract "Objective This study is set to investigate the antitumor activity of perindopril(PER) in combination with boanmycin(BAM). Methods The model of subcutaneously transplanted heptoma 22 in mice was used to evaluate the therapeutic effect.Results In all in vivo experiments,PER(2 mg· kg~(-1)) was administered ig till the end of experiment.Different settings of PER and BAM combination included:(1) BAM(1 mg· kg~(-1)) was administered ip on d1,d4 and d7 after tumor inoculation.PER alone,BAM alone,and PER-BAM combination inhibited the growth of hepatoma 22 by 59.3 %,39.1% and 76.0%(CDI = 0.96),respectively,on day 19.(2) BAM(1 mg· kg~(-1)) was administered ip on d4,d7 and d10 after tumor inoculation.The growth of tumor in BAM(1 mg· kg~(-1)) group or PER(2 mg· kg~(-1)) was faster than that in PER-BAM combination group.On day 19,PER (2 mg· kg~(-1)) alone,BAM(1 mg· kg~(-1)) alone,and PER-BAM combination inhibited the growth of hepatoma 22 by 42.9%,3.9% and 76.6%(CDI = 0.66),respectively.Conclusion The antitumor effect of PER-BAM combination may show synergism." @default.
- W2391039863 created "2016-06-24" @default.
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- W2391039863 date "2006-01-01" @default.
- W2391039863 modified "2023-09-26" @default.
- W2391039863 title "The effect of perindopril in combination with boanmycin on the growth of transplanted heptoma 22 in mice" @default.
- W2391039863 hasPublicationYear "2006" @default.
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