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- W2391045054 abstract "Objective:To induce myeloma specific cytotoxic T cells response in vitro mediated by autologous dendritic cells generating from multiple myeloma(MM) patients.Methods:Monocytes isolated from the peripheral blood of MM patients were cultured in serum free medium with 800 U/ml GM CSF and 600 U/ml IFNα for 8 days to generate DCs.These DCs were pulsed by U 266 cells treated with mitomycin C and their lysates,and then incubated with autologus T lymphocytes for 5～7 days to induce antigen specific CTL.MTT assay was performed to examine the U 266 cell specific lysis.Results:DCs derived from MM patients carried a typical dendritic like morphology,they highly expressed CD86,CD54 and class II MHC molecule(HLA DR) on cell surface.Specific killing of U 266 cells mediated by DCs were tested with MTT assay.At an effector/target ratio of 20/1,specific cytotoxic activities against U 266 cells(28.0%±7.6% and 21.2%±5.4%,respectively),were observed,but without antigen stimulation,the killing rate was 11.7%±4.3%,without DC mediation,the killing rate was 15.6%±4.8% and 13.1%±5.5%(P0.01).Conclusion:U 266 specific CTL can be induced in vitro by dendritic cells pulsed with U 266 cells and their lysates." @default.
- W2391045054 created "2016-06-24" @default.
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- W2391045054 date "2002-01-01" @default.
- W2391045054 modified "2023-09-25" @default.
- W2391045054 title "Induction of specific cytotoxic T lymphocytes mediated by dendritic cells in multiple myeloma patients in vitro" @default.
- W2391045054 hasPublicationYear "2002" @default.
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