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- W2391069092 abstract "Objective:To observe the plasma level of interleukin(IL)-37 in patients with coronary heart disease(CHD) and explore the correlation between IL-37 and CHD. Method:A total of 90 CHD patients conformed by coronary angiography was divided into acute coronary syndrome(ACS) group(n=60) and stable angina pectoris(SAP) group(n=30),another 35 subjects with normal angiography results were selected as control group.Biochemical analysis was taken routinely.The level of plasma IL-37 was measured by ELISA and the frequency of CD4+CD25+ regulatory T cells(Tregs) was detected by flow cytometry. Result:①Compared with control group,the level of plasma IL-37 was significantly decreased in ACS and SAP group(both P0.05).The level of plasma IL-37 in ACS group was lower than that in SAP group(P0.05).②Compared with control group,the frequency of Tregs was significantly decreased in ACS and SAP group(both P0.05).However,there was no significant difference between ACS and SAP group.③The level of plasma IL-37 was positively correlated with the frequency of Tregs(r=0.564,P0.01),and was negatively correlated with CRP,TC and LDL-C(r=-0.431,-0.327,-0.653,all P0.05).Moreover,there was no correlation between plasma IL-37 and TG,HDL-C and FBG. Conclusion:Hyperlipoidemia may be contributed to the decreased level of plasma IL-37 in CHD patients,and the role of plasma IL-37 in atherosclerosis possibly related to the decreased frequency of Tregs." @default.
- W2391069092 created "2016-06-24" @default.
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- W2391069092 date "2013-01-01" @default.
- W2391069092 modified "2023-09-23" @default.
- W2391069092 title "Change and significance of plasma IL-37 level in patients with coronary heart disease" @default.
- W2391069092 hasPublicationYear "2013" @default.
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