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- W2391080179 abstract "Objective To study the relationship of gyrA and parC gene mutation and pump efflux in Pseudomonas aeruginosa clinical isolates of ciprofloxacin resistance.Methods The dilution method was used to determine minimum inhibitory concentration(MIC) with or without the efflux pump inhibitor Carbonyl Cyarude-3-chlorophcnylhydrazone(CCCP).Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) was used to detect the mutation of gyrA and parC.Results The MIC of 57%(55/97) ciprofloxacin-resistant strains could be significantly reduced by CCCP.The rate of gyrA single gene mutation was 65%,while the rate of gyrA and parC double gene mutation was 35%.No single gene mutation of parC could be found in the test.There was no statistics difference in gyrA or parC gene mutation between the strains with or without efflux pump.Conclusion In ciprofloxacin resistance mechanism of P.aeruginosa clinical isolates,both gyrA and parC gene mutation and pump efflux play very important roles,but might function independently." @default.
- W2391080179 created "2016-06-24" @default.
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- W2391080179 date "2008-01-01" @default.
- W2391080179 modified "2023-09-26" @default.
- W2391080179 title "Study on the relationship of gyrA and parC gene mutation and pump efflux in Pseudomonas aeruginosa clinical isolates of ciprofloxacin resistance" @default.
- W2391080179 hasPublicationYear "2008" @default.
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