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• W2391112820 abstract "ABSTRACTIntroduction: Disorders of lipid metabolism caused by genetic mutations, acquired risk factors and risk conditions, or both, are common in children. While some manifest clinical signs and symptoms, children with genetic mutations such as familial hypercholesterolemia are asymptomatic and generally of normal weight. Nonetheless, life-long elevation of cholesterol plays a key role in the initiation and progression of atherosclerosis, starting in childhood, and increases risk of premature cardiovascular disease-related events, such as myocardial infarction and stroke.Areas covered: Genetic mutations and acquired risk factors and conditions that cause dyslipidemia are outlined. Current guidelines for screening, interpretation of test results, implementation of therapy and monitoring are reviewed, and the role of genetic testing is discussed.Expert opinion: In addition to a heart healthy lifestyle, those with inherited disorders of lipid metabolism often benefit from timely medical intervention to redu..." @default.
• W2391112820 created "2016-06-24" @default.
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• W2391112820 date "2016-06-06" @default.
• W2391112820 modified "2023-09-24" @default.
• W2391112820 title "Screening for genetic mutations in children and adolescents with dyslipidemia: importance of early identification and implications of missed diagnoses" @default.
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• W2391112820 doi "https://doi.org/10.1080/21678707.2016.1189824" @default.
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