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- W2391136154 abstract "【Objective】To investigate the effect of ischemic postconditioning on NF-κB signaling pathway in early lung transplantation.【Methods】All 40 rabbits were randomly allocated to three different groups: sham-operation group(Sham, n=8), ischemia-reperfusion group(I/R) and ischemic postconditioning group(IPO) were 8 pairs in each group in which left lung orthotropic transplantations were done with three-cannulas technique. In the I/R group,perfusion was resumed by pulmonary artery release immediately after transplantation, whereas in the IPO group, 3cycles of 1-min reperfusion and 1-min reocclusion of pulmonary artery were applied as postcontioning before recovery of perfusion. The levels of NF-κB, TNF-α and expression of IKKβ m RNA in the lungs were examined. The pathological changes of the lung tissues were observed with hematoxylin-eosin(HE) staining.【Results】The levels of NF-κB and TNF-α concentration, expression of IKKβ m RNA and W/D were significantly lower in sham group than that in I/R group and IPO group(P 0.05), the levels of NF-κB and TNF-α concentration, expression of IKKβm RNA and W/D in IPO group were also lower than those in IR group(P 0.05). Histological examination showed that the lung injury in group IPO was less than that in I/R groups. 【Conclusion】Ischemic postconditioning can reduce ischemic reperfusion injury of lung transplantation, One of possible mechanisms is that ischemic postconditioning suppresses the activation of NF-κB signaling channel and inhibits expression of TNF-α in lung tissue." @default.
- W2391136154 created "2016-06-24" @default.
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- W2391136154 date "2015-01-01" @default.
- W2391136154 modified "2023-09-23" @default.
- W2391136154 title "Effect of ischemic postconditioning on NF-κB activation signaling pathway in early lung transplantation" @default.
- W2391136154 hasPublicationYear "2015" @default.
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