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- W2391160957 abstract "Tumor progression involves a series of complex interactions between infiltrating malignant cells and adjacent normal tissues. The cell surface receptor CD44 has been implicated as an active participant in a number of these interactions. Although assigned a variety of functions, it is the role of CD44 as a receptor for the glycosaminoglycan hyaluronan that is likely to be of most importance. The matrix macromolecule hyaluronan often becomes deposited in the tissue spaces immediately surrounding invasive tumors. As such, hyaluronan may function as a ligand for CD44-mediated locomotion or assemble into a protective matrix coat surrounding the tumor cells. Alternatively, the adjacent hyaluronan-rich matrices may serve as a barrier to migration, breached in part by aggressive cell types exhibiting a capacity for CD44-mediated hyaluronan endocytosis. The significance of tumor-associated hyaluronan accumulation as well as potential functions of CD44 – hyaluronan interactions are reviewed." @default.
- W2391160957 created "2016-06-24" @default.
- W2391160957 creator A5068148729 @default.
- W2391160957 date "1998-01-01" @default.
- W2391160957 modified "2023-09-27" @default.
- W2391160957 title "The role of CD44 as a cell surface hyaluronan receptor during tumor invasion of connective tissue" @default.
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- W2391160957 doi "https://doi.org/10.2741/a305" @default.
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