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- W2391171899 abstract "Objective To study the relationship between activity and virulence of secretory acid proteinase and extracellular phosphlipase of different Candida albicans isolated from various specimens.Methods 190 strains of Candida albicans were isolated from various specimens(sputum,blood,thrush,wound,secretion of vaginitis) of patients with Candida albicans infection in hospital.Milk-plate medium and egg-yolk medium were used respectively to test the activities of secretory acid proteinase and extracellular phosphlipase of Candida albicans.The suspension of two forms of Candida albicans(5×106CFU·mL-1) were injected to vein of tail in mice respectively in virulence test.The mortality and mean survival time of mice were observed in 1 month.The virulence was appreciated with the mean survival time of mice.Results All of 190 strains,the positive detectable rates of secretory acid proteinase and extracellular phosphlipase were 83.68% and 85.26%,respectively.Animal experimental results showed the activities of secretory acid proteinase and extracellular phospolipase in hyphal forms were significantly higher than that in spore form(P0.01,P0.05).The mortality of mice injected with hyphal forms was higher than that of mice injected with spore forms(P0.05)and the mean survival time of mice injected with hyphal forms was shorter than that of mice injected with spore forms(P0.01).Conclusion Secretory acid proteinase and extracellular phosphlipase are important virulence factors of Candida albicans.The activities of secretory acid proteinase and extracellular phosphlipase can be used as direct parameters for virulence of Candida albicans." @default.
- W2391171899 created "2016-06-24" @default.
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- W2391171899 date "2007-01-01" @default.
- W2391171899 modified "2023-09-26" @default.
- W2391171899 title "Relationship between activity and virulence of secretory acid proteinase and extracellular phosphlipase of Candida albicans" @default.
- W2391171899 hasPublicationYear "2007" @default.
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