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- W2391207959 abstract "Objective To systematically evaluate the effectiveness and safety of lisinopril and amlodipine on left ventricular mass and diastolic function in elderly patients with hypertension. Methods Cochrane library,PubMed,EMBASE,CNKI,CBM,VIP and WangFang Datebase were selected to search the randomized controlled trials that compared lisinopril with amlodipine in the treatment of hypertension from initiation establishment of database to November,2012. The quality of the included studies were evaluated according to the predefined inclusion and exclusion criteria and then meta-analysis was conducted by using RevMan 5. 1software. Results A total of 4 randomized controlled trials( 408 patients) were included. Meta-analysis results suggested that there were no significant differences in left ventricular mass index( MD =- 9. 79 95% CI- 27. 70 to 8. 12),left ventricular end diastolic diameter( MD = 0. 22 95% CI- 1. 57 to 2. 01),interventricular septal thickness( MD =- 0. 94 95% CI- 3. 16 to 1. 27),left ventricular posterior wall thickness( MD =- 1. 68 95% CI- 4. 82 to 1. 45),left ventricular mass( MD =- 6. 64 95% CI- 15. 84 to2. 56),systolic pressure( MD = 0. 42 95% CI- 2. 41 to 3. 25) and diastolic pressure( MD = 0. 80 95% CI- 1. 13 to 2. 73) between lisinopril and amlodipine group. But for E /A( MD = 0. 07 95% CI 0. 00 to 0. 13),amlodipine was superior to lisinopril.Conclusions The effectiveness of lisinopril and amlodipine on left ventricular mass and diastolic function in elderly patients with hypertensive have no significant difference. But in consideration of the cost,lisinopril has a better cost-effectiveness ratio." @default.
- W2391207959 created "2016-06-24" @default.
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- W2391207959 date "2014-01-01" @default.
- W2391207959 modified "2023-09-23" @default.
- W2391207959 title "The meta-analysis of the effects of lisinopril versus amlodipine on left ventricular mass and diastolic function in elderly patients with hypertension" @default.
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