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- W2391233071 abstract "Ferrocene and its derivatives reveal many special properties and they have been used in many areas.Nitrogen-containing heterocyclic ring compounds have good biological activities,especially,the 1,2,4-triazole derivatives have been given much attention in recent years.In order to evaluate the cytotoxic activity of ferrocene Schiff base in this paper,six novel ferrocene Schiff bases were synthesized through the reaction of ferrocene carboxaldehyde with 3-substituted-4-amino-1,2,4-triazole-5-thione and four new ferrocene acylhydrazone Schiff bases were also synthesized through the reaction of ferrocenecarboxaldehyde or acetylferrocene with acylhydrazine.Their structures were characterized by 1H NMR,IR,MS and element analysis.Their cytotoxic activities were evaluated in vitro by an 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay using human cervical cancer cells(Hela) and the results show that these compounds exhibited some cytotoxic activities against cancer cells.In addition,the results indicate that compound 2 presented stronger cytotoxic activities against cancer cells(Hela) than compound 4." @default.
- W2391233071 created "2016-06-24" @default.
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- W2391233071 date "2011-01-01" @default.
- W2391233071 modified "2023-09-22" @default.
- W2391233071 title "Synthesis and Cytotoxic Activities of Ferrocene Schiff Bases" @default.
- W2391233071 hasPublicationYear "2011" @default.
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