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- W2391237276 abstract "To destroy the endothelial cells in tumor vascular bed is a promising approach to the therapy of solid tumor. The key point is to find out markers for tumor vascular endothelial cells. To raise a monoclonal antibody against proliferative endothelial cells, the human umbilical cord vessel endothelial cells(HUCVE) was stimulated with culture supernatant from hepatoma cell(7721). After HUCVE proliferation, these were used as antigen to immunize Balb/c mice. A monoclonal antibody named BVE1, with subtype IgG2a was obtained and reacted with capillaries in frozen sections of majority of the malignant tissues (liver, stomach, colon, breast cancer, and leiomyosarcoma), but not reacted with capillaries in normal tissues. This antibody can inhibit the proliferation and migration of endothelial cells as well as a CDC effect in vitro. The antigen recognized by this antibody was a glycolipidprotein with sialic acid epitopes and with relative molecular mass (Mr) being 150 000. It could be a new marker for tumor vasculature. This antibody may present as a universal vector for the target therapy of solid tumors." @default.
- W2391237276 created "2016-06-24" @default.
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- W2391237276 date "1998-01-01" @default.
- W2391237276 modified "2023-09-25" @default.
- W2391237276 title "A marker for the proliferating vascular endothelial cells in tumor" @default.
- W2391237276 hasPublicationYear "1998" @default.
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