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- W2391244554 abstract "AIM To investigate the influence of CYP2D6 genetic polymorphism on pharmacokinetics of paroxetine in Chinese healthy people.METHODS Twenty-three Chinese volunteers genotyped for CYP2D6 were separated into three groups by PCR-RFLP:CYP2D6*1/*1 group(n = 5),CYP2D6*1/*10 group(n = 7), and CYP2D6*10/*10 group(n = 11).After administration of a single oral dose of paroxetine hydrochloride tablet 20 mg,blood samples were collected at various time points until 96 h.The plasma concentrations of paroxetine were measured by LC-MS/MS method and the pharmacokinetics disposition of them was analyzed. RESULTS Compared with CYP2D6*1/*1 group,the t_(max) and t_(1/2) in CYP2D6*1/*10 group and t_(max) in CYP2D6*10/*10 group had no significant differences(P0.05);ρ_(max),AUC_(0-96h),AUC_(0-∞),CL(F) and V_d of paroxetine in CYP2D6*1/*10 group and CYP2D6*10/*10 group,and t_(1/2) in CYP2D6*10/*10 group all had significant differences(P 0.05 and P 0.01).CONCLUSION The allelic gene mutations of CYP2D6*10 can cause the changes of metabolic phenotype and have effects on the metabolism of paroxetine in healthy human body." @default.
- W2391244554 created "2016-06-24" @default.
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- W2391244554 date "2012-01-01" @default.
- W2391244554 modified "2023-09-26" @default.
- W2391244554 title "Influence of CYP2D6 genetic polymorphism on pharmacokinetics of paroxetine in Chinese healthy people" @default.
- W2391244554 hasPublicationYear "2012" @default.
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