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- W2391273465 abstract "Objective To study the effect of Enteromorpha's polysaccharide(EP) on lipid metabolism in type 2 diabetes.Methods A model of type 2 diabetes in rats was established by feeding high sugar and fat diet and an injection of STZ.The rats were then given po daily 150,300 or 600 mg/(kg bw) EP for 4 w.After 4w,serum TC,TG,HDL,LDL-C,MDA levels,SOD and GSH-Px activities were measured.The pathological changes of liver and pancreas were also observed by HE staining and the mRNA level of adiponectin(APN) in adipose tissue was detected by real time-PCR.Results The diabetic symptoms such as listlessness,hypotrichosis,polydypsia,polyphagia,polyuria,emaciation in EP groups were lighter than those in model group.Compared with the control group,the levels of TC,TG,HDL and in model group were significantly increased(P0.01).Compared with the model group,the levels of TG and MDA were significantly reduced(P0.01) in all EP groups;TC,LDL-C significantly reduced and HDL-C/TC increased in high and middle dose EP groups(P0.01).SOD activities were increased in high dose EP group(P0.05).GSH-Px activities and mRNA level of APN were increased(P0.05) in high and middle dose EP groups.The steatosis of hepatic cells and the pancreatic pathological damage were lighter in all EP groups.Conclusion EP can regulate lipid metabolism in type 2 diabetes.[ACTA NUTRIMENTA SINICA,2013,35(2):181-185]" @default.
- W2391273465 created "2016-06-24" @default.
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- W2391273465 date "2013-01-01" @default.
- W2391273465 modified "2023-09-26" @default.
- W2391273465 title "EFFECTS OF ENTEROMORPHA'S POLYSACCHARIDE ON LIPID METABOLISM AND ADIPONECTIN GENE EXPRESSION IN TYPE 2 DIABETIC RATS" @default.
- W2391273465 hasPublicationYear "2013" @default.
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