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- W2391275146 abstract "Objective:To study the effect of mifepriostone on expression of heme oxygenase-2(HO-2)and apoptosis in early chorionic trophoblastic cells.Methods:Eighty patients(40 patients with mifepristone and other 40 patients with artificial abortion)with early pregnancy were investigated.The expressions of HO-2 proteins were detected by using immunohistochemistry.The apoptosis of villi trophocytes was examined by terminal deoxyribonucleotidal transferase-mediated dUTP nick end labeling(TUNEL).Result:The expression of HO-2 in mifepristone group was lower than that in artificial abortion group(t=5.88,P0.001)but the apoptosis index(AI)of the villi trophocytes was significantly higher than that in artificial abortion group(t=6.02,P0.001).There was a negative correlation between expression of HO-2 and AI of the villi trophocytes in both groups.Conclusion:HO-2 play a role in the normal early pregnancy.Mifepristone may promote abnormal apoptosis of chorionic trophocytes via decreased expression of HO-2." @default.
- W2391275146 created "2016-06-24" @default.
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- W2391275146 date "2010-01-01" @default.
- W2391275146 modified "2023-09-23" @default.
- W2391275146 title "Effect of mifepriostone on expression of heme oxygenase-2(HO-2) and apoptosis in early chorionic trophoblastic cells" @default.
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