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- W2391298988 abstract "Objective: To explore the effects of gentiana scabra bage on the expression of hepatic TIMP-1 in Paragonimus skrjabini infected rats with liver fibrosis.Methods: Forty two SD rats were divided into 4 groups: normal comparing group,model group,interferon-γ group,gentiana scabra bage group.Use Paragonimus skrjabini infected rats,made them into liver fibrosis model.The rats were killed at the end of the twelfth weeks,TIMP-1 mRNA were detected in liver samples with RT-PCR.Results: Compared with the normal group,the expression of TIMP-1 mRNA in the model group expressly raised(P0.05).However,compared with the model group,the expression of TIMP-1 mRNA in the interferon-γ group and the gentiana scabra bage group was obviously weakened(P0.05).Conclusion: Gentiana scabra bage treatment could reduce the TIMP-1 significantly in Paragonimus skrjabini rats with liver fibrosis,thereby,played its role against hepatic fibrosis." @default.
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- W2391298988 date "2010-01-01" @default.
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- W2391298988 title "Effects of gentiana scabra bage on the expression of hepatic TIMP-1 in Paragonimus skrjabini infected rats with liver fibrosis" @default.
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