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- W2391323314 abstract "OBJECTIVE:To investigate the effects of water extracts of Panax ginseng(warm),dry P.ginseng(mild),P.quinque folium(cool) on the apoptosis of SH-SY5Y cells induced by β-amyloid protein(Aβ25-35).METHODS:SH-SY5Y cells were treated with Aβ25-35 to simulate the pathologic neuronic damage model in patients with Alzheimer's disease,and then treated with different doses of water extracts of P.ginseng(WERG),dry P.ginseng(WEG)or P.quinque folium(WEAG).The morphologic changes of the SH-SY5Y cells were observed by inverted microscope.Cell survival rate was measured by MTT assay.The percentage of apoptosis and the expression of Bax and Bcl-2 proteins were detected by Western Blotting.RESULTS: After treatment with Aβ25-35 50 μmol·L-1 for 72 hours,SH-SY5Y cells became more round and aggregated and the cell survival rate was significantly reduced(P0.01)but the percentage of apoptosis increased significantly(P0.01).The concomitant treatment of Aβ25-35 50 μmol·L-1 plus different doses of WERG,WEG or WEAG markedly attenuated cell damage and apoptosis but increase the survival rate of SH-SY5Y cells and markedly reduced the Bax/ Bcl-2 ratio.CONCLUSION:P.ginseng,Dry P.ginseng and P.quinque folium have different degree of protective effects on SH-SY5Y cells against apoptosis induced by Aβ25-35, of the 3 extracts,the P.ginseng is more potent in efficacy than the other two extracts." @default.
- W2391323314 created "2016-06-24" @default.
- W2391323314 creator A5063977635 @default.
- W2391323314 date "2009-01-01" @default.
- W2391323314 modified "2023-09-26" @default.
- W2391323314 title "Apoptosis Expression-based Pattern Recognition System for Four Natures of Chinese Materia Medica——Comparative Study on Drug Natures of the Water Extracts of Panax ginseng,Dry Panax ginseng and Panax quinque folium against Aβ_(25-35)-induced Apoptosis of" @default.
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