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- W2391330235 abstract "Objective To evaluate levels of free radicals(NO and MDA), NOS activity and radical eliminating enzymes (SOD and GSH-Px) with or without hyperbaric oxygen therapy after CO poisoning in mice brain; and effect of L-NAME on the damage of the blood-brain barrier caused by carbon-monoxide. Methods Mice were divided into different groups randomly (control, CO exposure, CO plus NBO therapy,CO plus HBO therapy). Brain samples were collected and a series of parameters were measured including NO,NOS,MDA, SOD, GSH-Px, and CAT. The changes of blood-brain barrier permeability were determined by detection of EB content with spectrophotometer.Results After CO poisoning , NO content and NOS activity decreased, MDA content increased and SOD activity decreased while activities of GSH-Px and CAT went up. After HBO therapy NOS activity recovered, and MDA producing was inhibited; GSH-Px continued to be upregulated, and CAT returned to baseline level. The permeability of blood-brain barrier was increased after acute carbon monoxide poisoning and the protection could be achieved by the application of L-NAME ( a NOS inhibitor)15 min before or 30 min after carbon monoxide exposure. Conclusion There are obvious changes of free radicals and process as lipid hyperoxidation happed after CO poisoning in mice brain. HBO therapy attenuates the injury. Enzymes of anti-oxygenation eliminate free radicals to some extent. HBO facilitates the process. The blood-brain barrier injury caused by CO poisoning may be partially mediated by NO, and L- NAME use could have clinical benefits." @default.
- W2391330235 created "2016-06-24" @default.
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- W2391330235 date "2004-01-01" @default.
- W2391330235 modified "2023-09-25" @default.
- W2391330235 title "Changes of free radicals and free radical scavenger in mice brain after carbon monoxide exposure" @default.
- W2391330235 hasPublicationYear "2004" @default.
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