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- W2391330288 abstract "Objective:To investigate the correlations of apoptosis-associated protein including caspase-3, bcl-2/bax expressions, the clinical pathological features of cholangiocarcinoma, and the relation between expressions of caspase-3, bcl-2 and bax in cholangiocarcinoma.Methods:SP immunohistochemistry was used to detect the expression of caspase-3, bcl-2/bax protein in 38 cases with cholangiocarcinoma Results:①The positive rate of caspase-3, bcl-2 and bax in well-differentiated cholangiocarcinoma respectively were 50%(9/18), 16.67%(3/18) and 44.4%(8/18), The positive rate of caspase-3 and bax were lower than that in poorly differentiated cholangiocarcinoma 1.82%(2/11) and 9.09%(1/11) (P0.05); and the positive rate of bcl-2 was higher than that in poorly differentiated cholangiocarcinoma 54.54%(6/11) (P0.05);②The degree of the expression of caspase-3, bcl-2 and bax had a significant correlation with poor differentiation and clinical TNM stage of cholangiocardinoma.Conclusion:The expression of apoptosis-associated protein including caspase-3, bcl-2/bax in cholangiocarcinoma tissues may be associated with cholangiocarcinoma and its progression;To some extent, caspase-3, bcl-2 and bax protein can predict the prognosis of cholangiocarcinoma.Molecular targets of caspase-3, bcl-2 and bax may also be important factors to be considered in the pathogenesis of cholangiocardinoma" @default.
- W2391330288 created "2016-06-24" @default.
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- W2391330288 date "2009-01-01" @default.
- W2391330288 modified "2023-09-25" @default.
- W2391330288 title "Correlations of Caspase-3, Bcl-2/Bax Protein Expressions with Clinical Pathological Features of Cholangiocarcinoma" @default.
- W2391330288 hasPublicationYear "2009" @default.
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