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- W2391330810 abstract "Objective To investigate the dynamic changes of serum P-selectin in different types of acute coronary syndrome(ACS) and clinical values thereof.Methods Peripheral blood samples were collected from 43 patients with ACS,including 18 cases of unstable angina pectoris(UA) and 25 cases of acute myocardiac infarction(AMI),15 stable angina(SA),and 15 healthy persons,all sex,age,blood lipid,and blood glucose-matched.All patients underwent thrombolysis therapy,coronary artery recanalization was achieved in 15 patients and failed to be achieved in 10 patients.ELISA was used to measure the serum P-selectin before and 3,6,and 12 hours after the treatment.Results The P-selectin of the SA patients was(11.9±3.7)ng/ml,not significantly different from that of the normal controls [(9.6±4.9)ng/ml,t=1.83,P 0.05].The P-selectin of the UA and AMI patients were(25.7±15.3) and(44.3±19.1)ng/ml respectively,both significantly higher than that of the normal control group(t= 3.88 and 3.21,both P0.01),and the P-selectin level of the AMI patients was significantly higher than that of the UA group(t=3.49,P0.01).The P-selectin level 3 hours after thrombolysis of the coronary artery recanalization group was(66.5±14.8)ng/ml,significantly higher than that of the non-coronary artery recanalization group [(50.3±10.6)ng/ml,t=2.98,P 0.01].The P-selectin level of the coronary artery recanalization group began to decrease 6 h after thrombolysis and dropped to the normal level 12 h after thrombolysis,however,the P-selectin level of the non-coronary recanalization group continued to increase.The CK-MB level of the recanalization group peaked to(928.4±86.8)μmol/L 12 h after thrombolysis,and the CK-MB level of the non-recanalization group peaked to(986.4±91.7)μmol/L 12 h after thrombolysis.Conclusion The serum P-selectin level is related to the severity of ACS and to the recanalization degree of the obstructed vessels after thrombolytic therapy.Dynamic serum P-selectin measurement can not only differentiate the severity of ACS,but also be used as an indirect index of the success of thrombolytic therapy." @default.
- W2391330810 created "2016-06-24" @default.
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- W2391330810 date "2008-01-01" @default.
- W2391330810 modified "2023-09-22" @default.
- W2391330810 title "Dynamic changes of serum P-selectin level in acute coronary syndrome and clinical value thereof" @default.
- W2391330810 hasPublicationYear "2008" @default.
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