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- W2391347838 abstract "Objective To investigate the effect of ginseng polysaccharide on the gene expression profile of human erythroleukemia K562 cells cultured in vitro.Methods The total RNAs treated with ginseng polysaccharide for 48 h were extracted from both K562 cells and the control K562 cells.All the RNAs were purified into mRNA and then convened to double-stranded cDNAs by reverse transcription.The cDNAs were labeled with a fluorescence dye Cy3 or Cy5 and hybridized to a Illumina whole-genome oligonucleotide microarray.The change in the gene expression profile of K562 cells following treatment with ginseng polysaccharide was analyzed by using bioinformatics.Results A total of 306 differential genes were found.Of which 220 were up-regulated and 86 were down-regulated.Their biologic function was classified.Conclusion Tumor cell differentiation is multiple genes comprehensive results,the screening of the genes may be meaningful for understanding tumorigenesis,tumor development,reverse polarization,and finding potential drug targets." @default.
- W2391347838 created "2016-06-24" @default.
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- W2391347838 date "2011-01-01" @default.
- W2391347838 modified "2023-09-23" @default.
- W2391347838 title "Effect of ginseng polysaccharide on gene expression profile of K562 cells" @default.
- W2391347838 hasPublicationYear "2011" @default.
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