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- W2391356723 abstract "Objective: To investigate the relationship between hepatitis B viral infection and hepatocellular carcinoma. Methods: Based on the detection of HBsAg and HBV DNA in the liver tissue of chronic hepatitis, liver cirrhosis, hepatocellular carcinoma and paratumor by immunohistochemistry and in situ hybridization respectively, the cases with both HBsAg and HBV DNA positive were detected using double labeling technique. Results: The positive rates and signals of HBsAg and HBV DNA were greater in chronic hepatitis, liver cirrhosis and paratumor than those in hepatocellular carcinoma. Most of HBV DNA in hepatocellular carcinoma was in nucleus and HBV DNA in chronic hepatitis, liver cirrhosis and paratumor was in cytoplasm or nucleus. HBsAg and HBV DNA coexisted in a single cell or distributed in different liver lobules or different parts of the same lobule. Conclusion: Most of hepatocellular carcinoma was associated with chronic hepatitis and liver cirrhosis infected by hepatitis B virus. Double labeling was a useful method to analyze the correlation of two different viral markers." @default.
- W2391356723 created "2016-06-24" @default.
- W2391356723 creator A5091670895 @default.
- W2391356723 date "2007-01-01" @default.
- W2391356723 modified "2023-09-23" @default.
- W2391356723 title "Hepatitis B Virus in Liver Tissue of Hepatocellular Carcinoma and Related Chronic Liver Diseases" @default.
- W2391356723 hasPublicationYear "2007" @default.
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