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- W2391373240 abstract "Objective To study the adhesion and dissemination of multicellular aggregates(MCAs) on extra cellular matrix(ECM) in human ovarian carcinoma.Methods MCAs were generated by the liquid overlay technique.MCAs,MCAs with monoclonal antibody(mAb) of four cell adhesion molecules(CD29,CD44,CD54 and(E-cad)) and MCAs with mIgG(control) were incubated in serum-free media on 96-wells coated with ECM for 6 h.MCAs at 0 and 6 h were counted,respectively,and MCAs dissemination was determined as the fold change in area of MCAs from 0 to 24 h. Results The adhesion rate of MCAs to ECM was 38%,significantly higher than that of the control group(8%,P=0.001).CD29 mAb and CD44 mAb partially inhibited MCAs adhesion,and the rate of inhibition was 60% and 29%,respectively.MCAs were seeded and completely disaggregated on ECM,resulting in a 5.96±0.92 fold change in area after 24 h compared with the control group(1.34±0.9,P0.01).CD29 mAb and CD44 mAb significantly inhibited the dissemination,and the inhibition rate was 74% and 33%,respectively.(Conclusion)The adhesion and dissemination of MCAs may contribute to the difficulties in treating ovarian carcinoma.CD29 and CD44 play an important role in facilitating ovarian cancer invasion and dissemination,indicating that ovarian carcinoma may be well suited for CD29 mAb and CD44 mAb mediated anti-adhesion therapy." @default.
- W2391373240 created "2016-06-24" @default.
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- W2391373240 date "2006-01-01" @default.
- W2391373240 modified "2023-09-23" @default.
- W2391373240 title "Adhesion and Dissemination of Multicellular Aggregates on Extra Cellular Matrix in Human Ovarian Carcinoma" @default.
- W2391373240 hasPublicationYear "2006" @default.
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