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- W2391375653 abstract "A model test by fed guinea pigs(DHP-Enl sp.)with Keshan disease(KD)endemic cereasls from Yunnan province for 10 weeks,the results have shownthat,the selenium(Se)level and glutathione peroxidase(GSH-Px)activity inplasma,red blood cell(rbc)and myocardial mitochondria in test-animals werelower than that of nonendemic group significantly.The activity of catalase inrbc decreased in some extent.Even the superoxide dismutase activity showed atendency to compensatory increasing,but the levels of conjugated diens andfluorescent chromolipids all the products of peroxidation of membrane lipids byactive oxygen free radicals still increased significatly.The cardiolipin(CL)content and cytochrome c oxidase activity(CCO)inmitochondria of test group were lower than that of control,and its circulardichroism(CD)also abnormal,but the endemic group supplemented with veget-able,in proportion as rising of Se and CL content in tissues the enzymicactivity and CD spectra of mitochondrial CCO were all restored to the normallevel of controls.The CD spectra of mitochondria,submitochondrial particle andCCO all appeared a resemble correspondent changes.Namely,the peak value inendemic cereal groups were all lower significantly。than that of controls.Themolecular pathological mechanism in pathogenesis of KD is discussed in thispaper。" @default.
- W2391375653 created "2016-06-24" @default.
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- W2391375653 date "1990-01-01" @default.
- W2391375653 modified "2023-09-24" @default.
- W2391375653 title "Changes in anti-oxidant ability,cytochrome c oxidase activity and circular dichroism of myocardial mitochondria in keshan disease model" @default.
- W2391375653 hasPublicationYear "1990" @default.
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