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- W2391378314 abstract "Objective To study the effect of glial cell line derived neurotrophic factor(GDNF) on the promotion of neurite outgrowth and axonal regeneration.Methods Dorsal root ganglions(DRG) from fetal rats were cultured and randomly divided into two groups.The control group was fed with culture media,and the GDNF group was fed with culture media plus GDNF.Three days after adding GDNF,the neurite outgrowth was evaluated by immunofluorescence staining.In vivo experiment,thirty-six adult SD rats were undergone T10 level right side spinal cord hemi-section,and randomly divided into two groups.The GDNF group transplanted with mini-channel filled with Schwann cells plus GDNF,while the control group had Schwann cells only.The sizes of regenerated axon cables were measured 2,4,and 6 weeks after transplantation.Results Three days after GDNF addition,the neurites outgrowth in GDNF group was much longer than that in control group,as well as the area covered by these neurites.At different time points after transplantation,the sizes of regenerated axon cables in the Schwann cell channels containing GDNF were much bigger than those without GDNF.Conclusion GDNF has significant effect in the promotion of neurites generation both in in vitro and in vivo,which can serve as candidate for the treatment of spinal cord injury." @default.
- W2391378314 created "2016-06-24" @default.
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- W2391378314 date "2011-01-01" @default.
- W2391378314 modified "2023-09-28" @default.
- W2391378314 title "Experimental Research of GDNF for Promoting the Axonal Regeneration after Spinal Cord Injury" @default.
- W2391378314 hasPublicationYear "2011" @default.
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