Matches in SemOpenAlex for { <https://semopenalex.org/work/W2391388820> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2391388820 abstract "Objective To define whether there is an association of the ACT-51 G/T polymorphism and AD in Chinese population. Methods Our samples were recruited from the outpatient clinics and population-based epidemiological survey. The diagnosis of AD met with criteria of NINCDS/ ADRDA about probable AD, and the degree of severity was according to the GDS. All AD patients conducted cranial CT or MRI. The real time PCR method was used to detect the SNP. Multiple logistic regression and chi square test were performed to explore the risk factor for AD. Results The frequency of G/G, G/T and T/T genotype were 12.50%,42.83% and 44.67% respectively among AD patients, and 12.57%,52.24% and 35.19% respectively among non-dementia controls. The individuals with T/T genotype had increased risk for AD (OR for T/T vs G/G: 1.55, 95%CI: 1.20~2.00, P=0.003). Adjusted for age and sex, the risk of T/T and G/T genotypes for AD was still detected. In multivariate analysis, T/T and G/T genotypes of IL-1α-889, age≥65 years and female were risk factors for AD. Adjusted for the age and sex, T/T and G/T genotypes were still associated with AD. The OR for AD was 3.55 and 1.55 for individuals with T/T and G/T genotypes compared with individuals with G/G (genotypes.) Conclusions The ACT-51 polymorphisms is likely to be a susceptibility factor for development of AD in Chinese Han population.There is an apparent gene-environment interaction among the susceptibility genotype, age and sex." @default.
- W2391388820 created "2016-06-24" @default.
- W2391388820 creator A5014145598 @default.
- W2391388820 creator A5026975632 @default.
- W2391388820 creator A5027313468 @default.
- W2391388820 creator A5032526910 @default.
- W2391388820 creator A5065346031 @default.
- W2391388820 date "2005-01-01" @default.
- W2391388820 modified "2023-09-26" @default.
- W2391388820 title "Association of α-antichymotripsin Polymorphism and Alzheimer Disease in Chinese Han Population" @default.
- W2391388820 hasPublicationYear "2005" @default.
- W2391388820 type Work @default.
- W2391388820 sameAs 2391388820 @default.
- W2391388820 citedByCount "0" @default.
- W2391388820 crossrefType "journal-article" @default.
- W2391388820 hasAuthorship W2391388820A5014145598 @default.
- W2391388820 hasAuthorship W2391388820A5026975632 @default.
- W2391388820 hasAuthorship W2391388820A5027313468 @default.
- W2391388820 hasAuthorship W2391388820A5032526910 @default.
- W2391388820 hasAuthorship W2391388820A5065346031 @default.
- W2391388820 hasConcept C104317684 @default.
- W2391388820 hasConcept C107130276 @default.
- W2391388820 hasConcept C126322002 @default.
- W2391388820 hasConcept C135763542 @default.
- W2391388820 hasConcept C144024400 @default.
- W2391388820 hasConcept C149923435 @default.
- W2391388820 hasConcept C151956035 @default.
- W2391388820 hasConcept C2779134260 @default.
- W2391388820 hasConcept C2908647359 @default.
- W2391388820 hasConcept C50440223 @default.
- W2391388820 hasConcept C54355233 @default.
- W2391388820 hasConcept C71924100 @default.
- W2391388820 hasConcept C86803240 @default.
- W2391388820 hasConcept C99454951 @default.
- W2391388820 hasConceptScore W2391388820C104317684 @default.
- W2391388820 hasConceptScore W2391388820C107130276 @default.
- W2391388820 hasConceptScore W2391388820C126322002 @default.
- W2391388820 hasConceptScore W2391388820C135763542 @default.
- W2391388820 hasConceptScore W2391388820C144024400 @default.
- W2391388820 hasConceptScore W2391388820C149923435 @default.
- W2391388820 hasConceptScore W2391388820C151956035 @default.
- W2391388820 hasConceptScore W2391388820C2779134260 @default.
- W2391388820 hasConceptScore W2391388820C2908647359 @default.
- W2391388820 hasConceptScore W2391388820C50440223 @default.
- W2391388820 hasConceptScore W2391388820C54355233 @default.
- W2391388820 hasConceptScore W2391388820C71924100 @default.
- W2391388820 hasConceptScore W2391388820C86803240 @default.
- W2391388820 hasConceptScore W2391388820C99454951 @default.
- W2391388820 hasLocation W23913888201 @default.
- W2391388820 hasOpenAccess W2391388820 @default.
- W2391388820 hasPrimaryLocation W23913888201 @default.
- W2391388820 hasRelatedWork W1968660015 @default.
- W2391388820 hasRelatedWork W2034942619 @default.
- W2391388820 hasRelatedWork W2040958618 @default.
- W2391388820 hasRelatedWork W2066634105 @default.
- W2391388820 hasRelatedWork W2070340425 @default.
- W2391388820 hasRelatedWork W2084066938 @default.
- W2391388820 hasRelatedWork W2117346609 @default.
- W2391388820 hasRelatedWork W2165656156 @default.
- W2391388820 hasRelatedWork W2275775827 @default.
- W2391388820 hasRelatedWork W2377411290 @default.
- W2391388820 hasRelatedWork W2377988462 @default.
- W2391388820 hasRelatedWork W2406526675 @default.
- W2391388820 hasRelatedWork W2408963767 @default.
- W2391388820 hasRelatedWork W2419397690 @default.
- W2391388820 hasRelatedWork W2424387669 @default.
- W2391388820 hasRelatedWork W2438321426 @default.
- W2391388820 hasRelatedWork W2748006448 @default.
- W2391388820 hasRelatedWork W2890530376 @default.
- W2391388820 hasRelatedWork W3029212809 @default.
- W2391388820 hasRelatedWork W2169807793 @default.
- W2391388820 isParatext "false" @default.
- W2391388820 isRetracted "false" @default.
- W2391388820 magId "2391388820" @default.
- W2391388820 workType "article" @default.