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- W2391390605 abstract "Objective:To explore the pathogenesis of thrombophilia in severe preeclampsia patients.Methods:30 cases of severe preeclampsia patient's(study group) and 42 cases of normal late pregnant women's(control group) plasma levels of tissue factor(TF),tissue factor pathway inhibitor(TFPI),tissue-type plasminogen ativator(t-PA),plasminogen activator inhibitor-1(PAI-1),and plasminogen activator inhibitor-2(PAI-2) were measured by ELLISA.Results:There were no significant difference in gestational age and pregnant women' age between two groups.The plasma D-dimer levels in severe preeclampsia group were significant higher than control group,and so as the positive rates of FDP between two groups.The TF level(53.02±8.64)pg/ml in study group was significant higher than the level(30.84±9.04)pg/ml in control group(P0.01).However TFPI level(3.04±1.08)ng/ml in study group was significant lower than the level(5.13±0.93)ng/ml in control group(P0.01).The plasma levels of t-PA in study group and control group were(42.03±16.08)ng/ml and(67.12±18.91)ng/ml respectively,there was significant difference between two groups.Both PAI-1 plasma level(81.37±14.87)ng/ml and PAI-2 plasma level(469.14±29.20)ng/ml in severe preeclampsia patients were significant higher than PAI-1 plasma level(63.15±8.88)ng/ml and PAI-2 level(122.56±17.67)ng/ml in control group(P0.01).Conclusion:The thrombophilia in severe preeclampsia patients is associated with imbalance of plasma coagulation factors,vascular endothelial cells activation or damage and abnormal expression of coagulation factors in placenta may be the main cause." @default.
- W2391390605 created "2016-06-24" @default.
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- W2391390605 date "2008-01-01" @default.
- W2391390605 modified "2023-09-25" @default.
- W2391390605 title "The changes of coagulant and fibrinolytic factors in plasma of patients with severe preeclampsia" @default.
- W2391390605 hasPublicationYear "2008" @default.
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