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- W2391395873 abstract "Aim To research the effect of hydrogen sulfide( H2S) in paraventricular nucleus( PVN) on blood pressure and sympathetic nerve activity in rats.Methods In anesthetized rats,renal sympathetic nerve activity( RSNA) and mean arterial pressure( MAP) were recorded in vivo on a PowerLab data acquisition system.The PVN microinjections were performed with stereotaxic instrument.Results The bilateral PVN microinjection NaHS,( 0.1,1.0,5.0,10.0,20.0 nmol),a H2S donor,dose-dependently decreased the MAP and RSNA;the PVN microinjection L-Cysteine( 1 nmol),a H2S precursor which increased endogenous hydrogen sulfide level,also caused decreases in the MAP and RSNA,AOA( 10 nmol),a CBS inhibitor which inhibited the production of endogenous H2S,increased the MAP and RSNA significantly;while SAM( 10 nmol),the CBS agonist,had no significant effect on the MAP and RSNA.Conclusion H2S in PVN is involved in the regulation of blood pressure and sympathetic nerve activity." @default.
- W2391395873 created "2016-06-24" @default.
- W2391395873 creator A5009701602 @default.
- W2391395873 date "2013-01-01" @default.
- W2391395873 modified "2023-09-28" @default.
- W2391395873 title "Effect of hydrogen sulfide in paraventricular nucleus on blood pressure and sympathetic nerve activity in rats" @default.
- W2391395873 hasPublicationYear "2013" @default.
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