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- W2391404966 abstract "Objective To investigate the association of two polymorphisms of XPA with the risk of susceptibility to esophageal squamous cell carcinoma (ESCC) and gastric cardiac adenocarcinoma (GCA) in a population of high incidence region of Hebei Province. Methods Two polymorphisms of XPA (A23G, at position-4 from the ATG start condon and G709A, at codon 228, in exon 6) were genotyped by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) analysis in 327 ESCC patients, 253 GCA patients and 612 healthy controls. Results The overall genotype and allelotype distributions of XPA A23G in ESCC patients were significantly different from that in healthy controls(P 0.05 ). The A/G+G/G genotype significantly decreased the risk of developing ESCC compared with A/A genotype. Stratified analysis showed that the protective effect was more evident in non-smokers and smokers.The protective effect was more evident in subjects with negative history of UGIC. The overall genotype and allelotype distributions of XPA A23G in GCA patients were not significantly different from that in healthy controls(P 0.05 ). Compared with A/A genotype, A/G+G/G genotype significantly decreased the risk of GCA.When stratified for status, the genotype distributions of XPA A23G in GCA patients were significantly different from that in healthy controls(P 0.05 ). Compared with A/A genotype, A/G+ G/G genotype significantly decreased the risk of GCA in non-smoker group. Conclusion XPA23A/G+G/G genotype may be one of the factors that affect the risk of developing ESCC and GCA in population in the high incidence region of Hebei Province." @default.
- W2391404966 created "2016-06-24" @default.
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- W2391404966 date "2007-01-01" @default.
- W2391404966 modified "2023-09-23" @default.
- W2391404966 title "Corrdation of XPA Polymorphisms to the Risk of Squamous Cell Carcinoma and Gastric Cardia Adenocarcinoma" @default.
- W2391404966 hasPublicationYear "2007" @default.
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