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- W2391414854 abstract "Objective To study the relationship between apolipoprotein E(apoE) gene polymorphism and coronary heart disease and the effect of apoE gene polymorphism on plasma lipid and lipoprotein levels. Methods Polymerase chain reaction restriction fragment length polymorphism(PCR RFLP) were used for the detection of apoE genotype in 125 elderly patients with coronary heart disease and 116 elderly healthy controls. The plasma lipid and lipoprotein levels were measured by routine method. Results Six genotypes of apoE E2/2, E2/3, E3/3, E3/4, E4/4 and E2/4 were detected in both groups. There were statistically significant differences in apoE3/3 and e3 allele frequencies( P 0 05) and in apoE3/4 and e4 allele frequencies( P 0 05) between the patients and controls; plasma total cholesterol(TC) and low density lipoprotein cholesterol(LDL C) of the patients with coronary heart disease were significantly higher than those of the controls( P 0 05). Among different apoE genotypes (E2/3, E3/3, E3/4) of patients with coronary heart disease, there were statistically differences in TC and LDL C levels( P 0 05). Conclusions ApoE e4 allele is an important genetic marker, apoE gene polymorphism may affect coronary heart disease through plasma lipid and lipoprotein levels." @default.
- W2391414854 created "2016-06-24" @default.
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- W2391414854 date "2003-01-01" @default.
- W2391414854 modified "2023-09-25" @default.
- W2391414854 title "The clinical significance of the detection of apolipoprotein E polymorphism for coronary heart disease in the elderly" @default.
- W2391414854 hasPublicationYear "2003" @default.
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