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- W2391427681 abstract "Objective:To study the effect of Xingnaojing and Shengmai injection on the expression of aquaporin-4(AQP4) in rat brain tissue after intracerebral hemorrhage(ICH).Method: The ICH model was induced by injecting self-blood.Forty male Sprague-Dawley(SD) rats were randomly divided into ICH group(n=10),saline group(NS,n=10),Xingnaojing and Shengmai injection group(XNJSM,n=10),hirudin group(HIR,n=10).Six hours after model establishment,rats in XNJSM were received Xingnaojing of 2 mL · kg-1 and Shengmai of 10 mL · kg-1through intraperitoneal injection,once daily,the therapeutic course was 3 days;Hirudin(10 U in 5 μL) was injected into the hematoma in HIR.Hematoxylin and eosin staining was performed to examine perihematomal neurocyte morphological changes,and the expression of AQP4 in perihematomal tissue was determined by immunohistochemistry and Western bloting respectively after 72 h.Result: AQP4 positive cells and protein expression in perihematomal tissue was increased at 72 h after ICH,with significant difference to those in NS(P0.05),Compared with ICH,in XNJSM group and HIR group,perihematomal tissue morphological changes were improved obviously,and AQP4 expression was also decreased significantly(P0.05).Conclusion: XNJSM injection could play a neuroprotective effect by inhibiting the expression of AQP4 and alleviating cerebral edema after ICH." @default.
- W2391427681 created "2016-06-24" @default.
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- W2391427681 date "2012-01-01" @default.
- W2391427681 modified "2023-09-27" @default.
- W2391427681 title "Effect of Xingnaojing and Shengmai Injection on AQP4 after Intracerebral Hemorrhage in Rats" @default.
- W2391427681 hasPublicationYear "2012" @default.
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