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- W2391431334 abstract "Objective To observe the expression of vascular endothelial growth factor(VEGF) induced by chronic in-termittent hypoxia(CIH) in rats.Methods Seventy-two male Wistar rats were divided into three groups:intermittent hy-poxia group(IH),sham control group(SC),and unhandled control group(UC).Infusion of nitrogen for 30 seconds was fol-lowed by infusion of compressed air for 30 seconds into the exposure chambers.When ambient oxygen concenyration reached the nadir of 4%-6%,it was retunred to 21%.IH rats were subjected to such intermitent hypoxia every 60s for 8h / d;SC rats were similarly handled but received compressed air instead of nitrogen;whilst UC rats remained unhandled.The levels of VEGF in serum were detected at 3,6 and 9 weeks after experiment.The samples were analyzed with immuno-histcohemical methods.Results Serum VEGF levels in IH rats increased gradualy over time,and began to increase signif-icantly at 3 weeks [(193.16±102.13)pg / ml] in IH and[(154.08±89.79)pg / ml] in SC and UC rats[(118.13±64.26)pg / ml](P0.05,P0.01).The levels of VEGF in IH rats increased remarkably at 9 weeks compared with that in SC(P0.01).Serum VEGF levels in IH and SC rats both increased than UC rats(P0.05),Serum VEGF levels in IH rats showed posi-tive correlation with the time of intermittent hypoxia(P0.05).Conclusion CIH can induc increase in the expression of VEGF in rats and the levels of serum VEGF increase showed correlation with the damage of blood vessel endothelium function.The changes of VEGF levels suggest that VEGF has endothelium protection against chronic intermittent hypoxia." @default.
- W2391431334 created "2016-06-24" @default.
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- W2391431334 date "2009-01-01" @default.
- W2391431334 modified "2023-09-28" @default.
- W2391431334 title "Effects of intermittent hypoxia on the expression of VEGF in rats" @default.
- W2391431334 hasPublicationYear "2009" @default.
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