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- W2391434191 abstract "Objective To investigate the effect of lead exposure on CA1 active Extracellar signal regulated kinase 2(ERK2) of rat hippocampus tatraethylammonium(TEA).Methods For chronic lead exposure in vivo,pregnant female rats were given 0.2% lead acetate in their drinking water before breeding and throughout gestation and lactation.After weaning at postnatal 21 d,the pups were provided lead acetate in drinking water.Until 30 d,hippocampus was got as chronic exposure sample.For acute lead expose in vitro,the control postnatal 30 d rat brains were got.After 2 h stabilization,lead acetate or(and) TEA was added into the ACSF,the slice was collected at different time and CA1 was got.The active ERK2 was determined by westem blots.Results TEA increased active ERK2 10 min to 158% after the washout of TEA(P0.01) and no significant increase in active ERK2 either 2 or 25 min.lead acetate could inhibit increase of active ERK2 induced by TEA.Nifedipine,L-type voltage dependent Ca~(2+) Channels(L-VDCC)antagonist,prevented the increase of active ERK2 measured at 10 min.Conclusion lead exposure inhibits increase of ERK2 activity,which may be the reason of its inhibition of LTP and learning and memory." @default.
- W2391434191 created "2016-06-24" @default.
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- W2391434191 date "2007-01-01" @default.
- W2391434191 modified "2023-09-22" @default.
- W2391434191 title "The effect of lead exposure on active extracellar signal regulated kinase 2 induced by tetraethylammonium" @default.
- W2391434191 hasPublicationYear "2007" @default.
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