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- W2391438534 abstract "Objective To examine the effects of carvedilol in a murine model of viral myocarditis in- duced by coxsackievirus B3 infection(CVB3). Methods BALB/c mice were intraperitoneally inoculated with CVB3, 24 h after infection carvedilol (10 mg/kg) was orally administered for 7 or 14 consecutive days. Infection group and normal group were used with same dose PBS. Mice were killed at day 7 and 14. The survival rate and myocardial histopathology changes were observed. The HW/BW ratio, the myocardial IFN-γproduction, the cont- ent of malondialdehyde (MDA) and superoxide dismutase(SOD) were studied. Results Carvedilol improved the 14-day survival of the animals, attenuated myocardial lesions and decreased HW/BW ratio. On day 7, carvedilol group increased the myocardial IFN-γproduction and decreased the content of MDA more significantly than virus infection group. On day 14, in carvedilol group we found increased SOD and decreased MDA. Conclusion Carvedilol protects animals against CVB3-induced viral myecarditis. Carvedilol exerts some of its beneficial effects by boosting the production of IFN-γand by inhibiting peroxidants in addition to improving cardiac function." @default.
- W2391438534 created "2016-06-24" @default.
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- W2391438534 date "2007-01-01" @default.
- W2391438534 modified "2023-09-25" @default.
- W2391438534 title "Effects of carvedilol on IFN-γactivity and oxygen free radical in a murine model infected by the coxsackievirus B3-induced viral myocarditis" @default.
- W2391438534 hasPublicationYear "2007" @default.
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