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- W2391440483 abstract "AIM: To eva1uate the role of some suppressorgenes and egr-l gene expression in the newly established hu-man osteosarcoma cell line SOSP-96O7. METHODS: Thegene expression of Rb, p16, p53 and egr-l in SOSP-96O7cells were investigated by immunohistochemical staining andin situ hybridization and the loss of DCC suppressor gene inthe cells was detected with RT-PCR amp1ification. RESULTS: The human osteosarcoma SOSP-96O7 ce11 line had anormal expression of Rb, pl6 and wild type but not mutanttype p53 gene on protein and mRNA level. The expression ofDCC gene in the level of mRNA was observed by RT-PCRwhi1e there was no detectab1e egrus1 gene expression on protein and mRNA levels in this ce11 line. CONCLUSION: Theneop1astic transformation of SOSP-96O7 cell line may not berelated to the suppressor gene Rb, pl6, p53 and DCC but re-lated to the 1ow level expression or expression shut down ofegr-l, which provides some theoretical basis for furtherstudy on the mechanism of osteosarcoma and on the potentialuse of egr-1 based biological therapy in the treatment of hu-man osteosarcoma." @default.
- W2391440483 created "2016-06-24" @default.
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- W2391440483 date "1999-01-01" @default.
- W2391440483 modified "2023-09-22" @default.
- W2391440483 title "Detection and significance evaluation of some suppressor genes and egr-1 expression in the newly established human osteosarcoma cell line SOSP-9607" @default.
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