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- W2391444893 abstract "Objective To investigate the expression of gap junction protein connexin 43 (Cx43) in adenohypophyseal folliculo stellate cells (FSCs) in rat model of ovariectomy induced osteoporosis.Methods Osteoporosis models of rats were obtained by bilateral ovariectomy.40 female rats were equally randomized into ovariectomized group (OVX group) and sham operation control group (sham group). Total skeletal and spinal (L4～6) bone mineral density (BMD) of each rat were measured by DEXA.The expression of Cx43 in adenohypophyseal glands was detected with immunofluorescent histochemistry using laser scanning confocal microscopy (LSCM) .Results At the end of 6 weeks after operation,total skeletal BMD and L4～6 BMD of rats in OVX group were significantly lower than those in sham group ( P 0 01, P 0 01 ). The fluorescence of Cx43 was distributed in the cytoplasm and along the cell membrane of FSCs.Both Cx43 fluorescence intensity and Cx43 positive cell ratio were lower in OVX group than in sham group( P 0 01).Conclusions Osteoporosis can be determined by means of significantlly decreased BMD in OVX group. The reduced expression of Cx43 in FSCs after ovariectomy could be presumed to play certain role in OVX induced osteoporosis." @default.
- W2391444893 created "2016-06-24" @default.
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- W2391444893 date "2001-01-01" @default.
- W2391444893 modified "2023-09-23" @default.
- W2391444893 title "Expression of Connexin43 in adenohypophyseal folliculo-stellate cells in rat model of ovariectomy-induced osteoporosis — study with laser scanning confocal microscopy" @default.
- W2391444893 hasPublicationYear "2001" @default.
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