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- W2391446048 abstract "Objective Bronchial asthma(asthma) is a chronic disease characterized by airway inflammation,airway hyperresponsiveness,reversible airway obstruction and airway remodeling.Angiogenesis and microvascular remodeling may play a vital role in chronic inflammatory processes.Vascular endothelial growth factor(VEGF) is a potent angiogenic factor whose activities include endothelial cell survival,proliferation,and migration.In this study we hypothesized that an increased expression of VEGF may exist and complicate with airway remodeling in asthma patients.Budesonide-Formoterol can decrease the expressions of VEGF and VEGF receptor 1(VEGFR1) with airway remodeling in asthma.To this end,we examined the expression levels of VEGF and its receptor in bronchial tissues of patients with asthma to investigate the relationship between VEGF and airway remodeling and the efficiency of Budesonide-Formoterol on the airway remodeling.Methods Bronchial tissues were obtained from fiberoptic bronchoscopy and bronchial biopsy in West China Hospital from April to November in 2006.Thirteen patients were diagnosed as patients with moderate asthma,and other 10 were the control subjects.The patients with asthma were treated with Budesonide-Formoterol for 6 months.The expressions of VEGF and VEGFR1 in bronchial tissues were detected by immunohistochemical stain.Periodic Acid-Schiff (PAS) and alcian blue stain,and Masson Trichrome stain were performed to evaluate the degree of airway remodeling.Results The differences of age and gender between two groups were not significant.Otherwise,the differences of FVC %pred,FEV1 %Pred,PC20,V75%pred,V50%pred and V25%pred were significant between two groups.The patients with asthma had submucosal gland hyperplasia,increased smooth muscle mass,subepithelial fibrosis and neovascularization,compared to subjects in the control group.The asthma groups showed increased expressions of VEGF and VEGFR1,more positively-stained cells of airway epithelial cells than the control group.The up-regulated expressions of VEGF and its receptor well correlated with the airway remodeling,air flow obstruction and airway hyperresponsiveness.After treatment with Budesonide-Formoterol for 6 months,the expressions of VEGF and VEGFR1 have been decreased,with decreased airway remodeling in patients with asthma.Conclusions The increased expressions of VEGF and its receptor are accompanied by increased number and size of vessels in asthmatic airway,as well as airway remodeling.Budesonide-Formoterol can decrease the expressions of vascular endothelial growth factor and receptor 1 with airway remodeling in asthma.The inhibition of VEGF and its receptor may be a good therapeutic strategy for asthma." @default.
- W2391446048 created "2016-06-24" @default.
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- W2391446048 date "2008-01-01" @default.
- W2391446048 modified "2023-09-26" @default.
- W2391446048 title "Budesonide/formoterol decreases expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 1 within airway remodelling in asthma" @default.
- W2391446048 hasPublicationYear "2008" @default.
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